Part of the NMT BioFunction Research Platform series. The imFluxes-Tumor-100 is used for testing living organisms’ physiological functions, and it is designed specifically for testing O2 and H2O2.
While maintaining the integrity of the samples, it can detect O2 and H2O2 influx and efflux and has sensitivity as high as femto (10-15) moles • cm-2 • s-1.
This platform would be beneficial for research in areas such as target tumor therapy, drug screening, and apoptosis.
In-situ and non-invasive test on living samples
Provides information of samples in their normal physiological condition without damaging the samples
Can test and provide real-time data in as little as 5 seconds
Ionic and molecular measurements
This platform measures: O2 and H2O2
Additional sensor options: none
(Other NMT BioFunction Research Platforms are able to measure Ca2+, H+, K+, Na+, Cl-, Mg2+, Cd2+, NH4+, NO3-, O2, H2O2, and/or IAA)
Can provide real-time and dynamic detection for many hours
Without using the radioactive, chemical, pharmacological or other labeling methods, imFluxes-Tumor-100 allows researchers to detect the tested ions and molecules in advance in a safe and environmentally friendly manner.
High resolution and wide range of sample sizes
Temporal resolution: 3s (response time) and 5s (measurement time);
Spatial resolution of ions: 1µm- 10µm;
Spatial resolution of molecules: 20µm—25µm;
Flux Sensitivity: 10-15mol•cm-2•s-1
No need to extract samples
Can detect samples directly without using grinding and other traditional extraction methods
Capable of testing various samples
Intact organisms, organs, tissues, cells, and even small condensed organelles can be tested
3D Flux Measurements
Different platforms in the NMT BioFunction Research Platform series can detect one-dimensional measurements (NMT BioFunction Research Platforms are the exception, for they can detect three-dimensional measurements).
After upgraded, all platforms in the series can detect three-dimensional measurements and provide flux information by measuring the concentration gradient in all x, y, and z directions. At the same time, sample positioning will become more precise and flexible, thus enhancing the repeatability of the experiment.
For more published works, see our Publications page:
Research using NMT has been published in journals such as:
Tumor research using NMT includes:
- Song L, et al. O2 and Ca2+ Fluxes as Indicators of Apoptosis Induced by Rose Bengal–Mediated Photodynamic Therapy in Human Oral Squamous Carcinoma Cells. Photomedicine and Laser Surgery, 2015, 33(5): 258-265.
- Sheng LH, et al. Imbalance of Ca2+ and K+ fluxes in C6 glioma cells after PDT measured with scanning ion-selective electrode technique. Lasers in Medical Science. 2014, 29(3): 1261-1267.
|Motion Control Module ║ X-axis Motion Translation Stage|
|Motion Control Module ║ Y-axis Motion Translation Stage|
|Control||Lead screw drive|
|Motion Control Module ║ Z-axis Motion Translation Stage|
|Control||Lead screw drive|
|Motion Control Module ║ Lead screws|
|Motion Control Module ║ Supporting Stage|
|Material-top||M6 on 25mm|
|Adjustable supporting rod||150mm - 250mm|
|Signal Processing Module ║ Solid Reference Microelectrode|
|Temperature range||-5°C - 100°C|
|Wire length||2 m|
|Tip diameter||2 mm|
|Signal Processing Module ║ Pre-amplifier (Polarographical Head Stages)|
|Type||embedded current/voltage conversion|
|Signal Processing Module ║ Reference Microelectrode Holder|
|Linear Motion||adjustable solid sliding rail|
|Signal Processing Module ║ Ground Wire Bracket|
|Signal Processing Module ║ Data Acquisition System|
|Signal Acquisition mode||16 bits A/D conversion card|
|Signal Processing Module ║ High-gain Main Amplifier for Molecule Sensor|
|Input voltage & frequency||100-240V AC 50/60 Hz|
|Signal Processing Module ║ O2 Flux Sensor|
|Signal Processing Module ║ H2O2 Flux Sensor|
|Software ║ Non-invasive Ion & Molecule Flux Measurement Software V2.0|
|Data output format||MS Excel|
|Account Management||Multi user|
|Software module(s)||O2 measurement module; H2O2 measurement module|
|Supports Chinese input||yes|
|Potential/Slope value over range alarm module||yes|
|Data optimization module||yes|